Isibulala-magciwane sezokwelapha yidivayisi esebenzisa ukushisa, amakhemikhali, noma imisebe ukuze ibulale noma isuse zonke izinhlobo zama-microorganisms kanye namagciwane emishini yezokwelapha namathuluzi.Kuyithuluzi elibalulekile kunoma yisiphi isimo sokunakekelwa kwezempilo, njengoba lisiza ukuvimbela ukusabalala kwezifo nezifo.Inqubo yokuvala inzalo iphinde iqinisekise ukuthi amathuluzi ezokwelapha aphephile ukuthi angasetshenziswa ezigulini.Izibulala magciwane zezokwelapha ziza ngezinhlobo ezahlukene, okuhlanganisa ama-autoclave, izibulala-magciwane zamakhemikhali, nezibulala magciwane ngemisebe.Ama-autoclave asebenzisa isitimu nokucindezela ukuze abulale amathuluzi, kuyilapho izibulali magciwane zamakhemikhali zisebenzisa amakhemikhali afana ne-ethylene oxide.Izibulala-magciwane ezikhipha imisebe zisebenzisa imisebe ye-ionizing ukuze zibulale ama-microorganisms.Izibulala-magciwane zezokwelapha zidinga ukunakekelwa okufanele kanye nokuqapha ukuze kuqinisekiswe ukuthi zihlala zisebenza kahle.